Drug interactions
Enzalutamide + Glasdegib
Severity: Major
Enzalutamide and Glasdegib: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glasdegib is metabolized by CYP3A4, and strong inducers lower exposure. Enzalutamide may reduce its efficacy in AML.
What this interaction means in plain words
Enzalutamide and Glasdegib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Enzalutamide belongs to Endocrine; Glasdegib belongs to Oncology.
Why it happens
Enzalutamide induces CYP3A4, increasing glasdegib clearance.
What to do
Avoid combination; if unavoidable, increase glasdegib dose per labeling guidance and monitor response.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Glasdegib
- Amiodarone + Glasdegib Major
- Amisulpride + Glasdegib Major
- Amobarbital + Glasdegib Major
- Anagrelide + Glasdegib Major
- Apalutamide + Glasdegib Major
- Asenapine + Glasdegib Major
Frequently asked questions
Can I take Enzalutamide with Glasdegib?
MediHelp rates the interaction as major. Enzalutamide and Glasdegib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Glasdegib is metabolized by CYP3A4, and strong inducers lower exposure. Enzalutamide may reduce its efficacy in AML.
How serious is the interaction between Enzalutamide and Glasdegib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combination; if unavoidable, increase glasdegib dose per labeling guidance and monitor response.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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