Drug interactions
Enzalutamide + Lefamulin
Severity: Major
Enzalutamide and Lefamulin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Strong CYP3A and P-gp induction can lower lefamulin exposure and risk treatment failure in pneumonia. Enzalutamide is a strong CYP3A4 inducer.
What this interaction means in plain words
Enzalutamide and Lefamulin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Enzalutamide belongs to Endocrine; Lefamulin belongs to Anti Bacterial.
Why it happens
Enzalutamide induces CYP3A4 and P-glycoprotein, increasing lefamulin clearance.
What to do
Avoid unless benefit clearly outweighs risk, and consider an antibiotic not affected by induction. If used, monitor clinical response.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Lefamulin
- Lefamulin + Methadone Contraindicated
- Lefamulin + Pimavanserin Contraindicated
- Lefamulin + Pimozide Contraindicated
- Lefamulin + Quinidine Contraindicated
- Alfuzosin + Lefamulin Major
- Amiodarone + Lefamulin Major
Frequently asked questions
Can I take Enzalutamide with Lefamulin?
MediHelp rates the interaction as major. Enzalutamide and Lefamulin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Strong CYP3A and P-gp induction can lower lefamulin exposure and risk treatment failure in pneumonia. Enzalutamide is a strong CYP3A4 inducer.
How serious is the interaction between Enzalutamide and Lefamulin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unless benefit clearly outweighs risk, and consider an antibiotic not affected by induction. If used, monitor clinical response.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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