Drug interactions
Enzalutamide + Metformin-repaglinide
Severity: Moderate
Enzalutamide and Metformin-repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide is a strong CYP3A4 inducer and a CYP2C8 inducer, and can lower repaglinide exposure, leading to reduced glycemic control.
What this interaction means in plain words
Enzalutamide and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enzalutamide belongs to Endocrine; Metformin-repaglinide belongs to Endocrine.
Why it happens
Induction of CYP3A4 and CYP2C8, increasing repaglinide metabolism.
What to do
Monitor blood glucose after starting enzalutamide and increase the repaglinide dose if control worsens. Reassess the dose after enzalutamide is discontinued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Frequently asked questions
Can I take Enzalutamide with Metformin-repaglinide?
MediHelp rates the interaction as moderate. Enzalutamide and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enzalutamide is a strong CYP3A4 inducer and a CYP2C8 inducer, and can lower repaglinide exposure, leading to reduced glycemic control.
How serious is the interaction between Enzalutamide and Metformin-repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting enzalutamide and increase the repaglinide dose if control worsens. Reassess the dose after enzalutamide is discontinued.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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