Drug interactions
Enzalutamide + Nifedipine
Severity: Moderate
Enzalutamide and Nifedipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide is a strong CYP3A4 inducer and can substantially reduce nifedipine exposure, leading to loss of blood pressure or angina control.
What this interaction means in plain words
Enzalutamide and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enzalutamide belongs to Endocrine; Nifedipine belongs to Cardiovascular.
Why it happens
Enzalutamide induction of CYP3A4 increases nifedipine metabolism.
What to do
Monitor blood pressure and symptoms, and raise the nifedipine dose or switch to a non-CYP3A4 antihypertensive if response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nifedipine
Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Frequently asked questions
Can I take Enzalutamide with Nifedipine?
MediHelp rates the interaction as moderate. Enzalutamide and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enzalutamide is a strong CYP3A4 inducer and can substantially reduce nifedipine exposure, leading to loss of blood pressure or angina control.
How serious is the interaction between Enzalutamide and Nifedipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and symptoms, and raise the nifedipine dose or switch to a non-CYP3A4 antihypertensive if response is inadequate.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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