Drug interactions
Enzalutamide + Olutasidenib
Severity: Major
Enzalutamide and Olutasidenib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olutasidenib is a CYP3A4 substrate, and enzalutamide is expected to reduce its plasma levels. Efficacy in IDH1-mutated leukemia may be diminished.
What this interaction means in plain words
Enzalutamide and Olutasidenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Enzalutamide belongs to Endocrine; Olutasidenib belongs to Oncology.
Why it happens
Enzalutamide induces CYP3A4, accelerating olutasidenib metabolism.
What to do
Avoid concomitant use with enzalutamide and choose an alternative to the inducer. Monitor leukemia response if it cannot be avoided.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Olutasidenib
Frequently asked questions
Can I take Enzalutamide with Olutasidenib?
MediHelp rates the interaction as major. Enzalutamide and Olutasidenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Olutasidenib is a CYP3A4 substrate, and enzalutamide is expected to reduce its plasma levels. Efficacy in IDH1-mutated leukemia may be diminished.
How serious is the interaction between Enzalutamide and Olutasidenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use with enzalutamide and choose an alternative to the inducer. Monitor leukemia response if it cannot be avoided.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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