Drug interactions
Enzalutamide + Palovarotene
Severity: Major
Enzalutamide and Palovarotene: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Palovarotene is cleared by CYP3A4, and enzalutamide may reduce its exposure. This may decrease its ability to limit heterotopic ossification.
What this interaction means in plain words
Enzalutamide and Palovarotene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Enzalutamide belongs to Endocrine; Palovarotene belongs to Miscellaneous.
Why it happens
Enzalutamide induces CYP3A4, increasing palovarotene clearance.
What to do
Avoid combining with strong CYP3A inducers; consider an alternative to enzalutamide. Monitor clinical response if co-used.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Palovarotene
- Acitretin + Palovarotene Contraindicated
- Isotretinoin + Palovarotene Contraindicated
- Amiodarone + Palovarotene Major
- Amobarbital + Palovarotene Major
- Apalutamide + Palovarotene Major
- Aprepitant + Palovarotene Major
Frequently asked questions
Can I take Enzalutamide with Palovarotene?
MediHelp rates the interaction as major. Enzalutamide and Palovarotene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Palovarotene is cleared by CYP3A4, and enzalutamide may reduce its exposure. This may decrease its ability to limit heterotopic ossification.
How serious is the interaction between Enzalutamide and Palovarotene?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining with strong CYP3A inducers; consider an alternative to enzalutamide. Monitor clinical response if co-used.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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