Drug interactions
Enzalutamide + Pirtobrutinib
Severity: Major
Enzalutamide and Pirtobrutinib: major interaction.
Last updated Sources: EMA SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pirtobrutinib is a CYP3A4 substrate, and enzalutamide can lower its exposure, risking reduced antitumor activity.
What this interaction means in plain words
Enzalutamide and Pirtobrutinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Enzalutamide belongs to Endocrine; Pirtobrutinib belongs to Oncology.
Why it happens
Enzalutamide induces CYP3A4, increasing pirtobrutinib clearance.
What to do
Avoid strong CYP3A inducers with pirtobrutinib. If unavoidable, increase the pirtobrutinib dose per labeling and monitor response.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Pirtobrutinib
Frequently asked questions
Can I take Enzalutamide with Pirtobrutinib?
MediHelp rates the interaction as major. Enzalutamide and Pirtobrutinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pirtobrutinib is a CYP3A4 substrate, and enzalutamide can lower its exposure, risking reduced antitumor activity.
How serious is the interaction between Enzalutamide and Pirtobrutinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid strong CYP3A inducers with pirtobrutinib. If unavoidable, increase the pirtobrutinib dose per labeling and monitor response.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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