Drug interactions
Enzalutamide + Repaglinide
Severity: Moderate
Enzalutamide and Repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide is a strong CYP3A4 inducer and also induces CYP2C8, so it can lower repaglinide concentrations and weaken glycemic control. The induction develops over weeks and persists after enzalutamide is stopped.
What this interaction means in plain words
Enzalutamide and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enzalutamide belongs to Endocrine; Repaglinide belongs to Endocrine.
Why it happens
Enzalutamide induces CYP3A4 and CYP2C8, increasing repaglinide metabolism.
What to do
Monitor blood glucose after starting enzalutamide and increase the repaglinide dose if needed. Re-evaluate the dose after enzalutamide is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporin + Repaglinide Major
- Deferasirox + Repaglinide Major
Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Frequently asked questions
Can I take Enzalutamide with Repaglinide?
MediHelp rates the interaction as moderate. Enzalutamide and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enzalutamide is a strong CYP3A4 inducer and also induces CYP2C8, so it can lower repaglinide concentrations and weaken glycemic control. The induction develops over weeks and persists after enzalutamide is stopped.
How serious is the interaction between Enzalutamide and Repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting enzalutamide and increase the repaglinide dose if needed. Re-evaluate the dose after enzalutamide is stopped.
What other medicines interact with Repaglinide?
MediHelp also lists interactions of Repaglinide with, for example, Gemfibrozil, Clarithromycin, Clopidogrel. The full list is on the Repaglinide page.
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