Drug interactions
Enzalutamide + Selpercatinib
Severity: Major
Enzalutamide and Selpercatinib: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selpercatinib is a CYP3A4 substrate and strong inducers can substantially reduce its exposure. Enzalutamide may reduce antitumor activity.
What this interaction means in plain words
Enzalutamide and Selpercatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Enzalutamide belongs to Endocrine; Selpercatinib belongs to Oncology.
Why it happens
Enzalutamide induces CYP3A4, increasing selpercatinib clearance.
What to do
Avoid concomitant strong or moderate CYP3A inducers. Consider an alternative to enzalutamide and monitor tumor response if combined.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Selpercatinib
Frequently asked questions
Can I take Enzalutamide with Selpercatinib?
MediHelp rates the interaction as major. Enzalutamide and Selpercatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Selpercatinib is a CYP3A4 substrate and strong inducers can substantially reduce its exposure. Enzalutamide may reduce antitumor activity.
How serious is the interaction between Enzalutamide and Selpercatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant strong or moderate CYP3A inducers. Consider an alternative to enzalutamide and monitor tumor response if combined.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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