Drug interactions
Enzalutamide + Suvorexant
Severity: Moderate
Enzalutamide and Suvorexant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Strong CYP3A4 inducers reduce suvorexant exposure and its efficacy for insomnia. The labeling suggests this combination is best avoided.
What this interaction means in plain words
Enzalutamide and Suvorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enzalutamide belongs to Endocrine; Suvorexant belongs to Central Nervous System.
Why it happens
Enzalutamide induces CYP3A4, increasing suvorexant clearance.
What to do
Monitor sleep response and consider a different hypnotic not dependent on CYP3A4. If the dose is raised, stay within the labeled maximum.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Suvorexant
Frequently asked questions
Can I take Enzalutamide with Suvorexant?
MediHelp rates the interaction as moderate. Enzalutamide and Suvorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Strong CYP3A4 inducers reduce suvorexant exposure and its efficacy for insomnia. The labeling suggests this combination is best avoided.
How serious is the interaction between Enzalutamide and Suvorexant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sleep response and consider a different hypnotic not dependent on CYP3A4. If the dose is raised, stay within the labeled maximum.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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