Drug interactions
Enzalutamide + Tolterodine
Severity: Moderate
Enzalutamide and Tolterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide is a strong CYP3A4 inducer and can decrease tolterodine exposure. The effect is probably moderated by the CYP2D6 pathway, but reduced efficacy is possible.
What this interaction means in plain words
Enzalutamide and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enzalutamide belongs to Endocrine; Tolterodine belongs to Genitourinary.
Why it happens
Induction of CYP3A4 by enzalutamide increases tolterodine clearance.
What to do
Monitor for loss of bladder symptom control and raise the tolterodine dose or switch agent if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolterodine
Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Frequently asked questions
Can I take Enzalutamide with Tolterodine?
MediHelp rates the interaction as moderate. Enzalutamide and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enzalutamide is a strong CYP3A4 inducer and can decrease tolterodine exposure. The effect is probably moderated by the CYP2D6 pathway, but reduced efficacy is possible.
How serious is the interaction between Enzalutamide and Tolterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of bladder symptom control and raise the tolterodine dose or switch agent if needed.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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