Drug interactions
Epcoritamab + Quinidine
Severity: Moderate
Epcoritamab and Quinidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epcoritamab induces cytokine release that can temporarily suppress CYP450 enzymes. Quinidine is a CYP3A4 substrate with a narrow therapeutic index, so its levels may rise and increase QT prolongation risk. The effect is most relevant around step-up doses and any cytokine release syndrome.
What this interaction means in plain words
Epcoritamab and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Epcoritamab belongs to Oncology; Quinidine belongs to Anti Parasitic.
Why it happens
Cytokine-mediated suppression of CYP3A4 activity reduces quinidine metabolism.
What to do
Monitor ECG/QTc and quinidine levels during the first cycle and during any CRS. Adjust the quinidine dose if signs of toxicity develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Epcoritamab
- Epcoritamab + Ergotamine Major
- Epcoritamab + Pimozide Major
- Bendamustine + Epcoritamab Moderate
- Carbamazepine + Epcoritamab Moderate
- Clomipramine + Epcoritamab Moderate
- Clozapine + Epcoritamab Moderate
Frequently asked questions
Can I take Epcoritamab with Quinidine?
MediHelp rates the interaction as moderate. Epcoritamab and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epcoritamab induces cytokine release that can temporarily suppress CYP450 enzymes. Quinidine is a CYP3A4 substrate with a narrow therapeutic index, so its levels may rise and increase QT prolongation risk. The effect is most relevant around step-up doses and any cytokine release syndrome.
How serious is the interaction between Epcoritamab and Quinidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG/QTc and quinidine levels during the first cycle and during any CRS. Adjust the quinidine dose if signs of toxicity develop.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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