Drug interactions
Epcoritamab + Ramelteon
Severity: Moderate
Epcoritamab and Ramelteon: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epcoritamab triggers cytokine release that may transiently suppress CYP enzyme activity. Ramelteon exposure may rise, causing more sedation or dizziness.
What this interaction means in plain words
Epcoritamab and Ramelteon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Epcoritamab belongs to Oncology; Ramelteon belongs to Central Nervous System.
Why it happens
Cytokine-mediated suppression of CYP-mediated ramelteon metabolism (mainly CYP1A2, with minor CYP3A4).
What to do
Monitor for increased ramelteon effects around the first doses and during cytokine release syndrome. Reduce or hold ramelteon if excess drowsiness occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ramelteon
- Calcium / magnesium / potassium / sodium oxybates + Ramelteon Contraindicated
- Fluvoxamine + Ramelteon Contraindicated
- Ramelteon + Sodium oxybate Contraindicated
- Alfentanil + Ramelteon Moderate
- Amitriptyline + Ramelteon Moderate
- Amobarbital + Ramelteon Moderate
Other interactions of Epcoritamab
- Epcoritamab + Ergotamine Major
- Epcoritamab + Pimozide Major
- Bendamustine + Epcoritamab Moderate
- Carbamazepine + Epcoritamab Moderate
- Clomipramine + Epcoritamab Moderate
- Clozapine + Epcoritamab Moderate
Frequently asked questions
Can I take Epcoritamab with Ramelteon?
MediHelp rates the interaction as moderate. Epcoritamab and Ramelteon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epcoritamab triggers cytokine release that may transiently suppress CYP enzyme activity. Ramelteon exposure may rise, causing more sedation or dizziness.
How serious is the interaction between Epcoritamab and Ramelteon?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased ramelteon effects around the first doses and during cytokine release syndrome. Reduce or hold ramelteon if excess drowsiness occurs.
What other medicines interact with Ramelteon?
MediHelp also lists interactions of Ramelteon with, for example, Calcium / magnesium / potassium / sodium oxybates, Fluvoxamine, Sodium oxybate. The full list is on the Ramelteon page.
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