Drug interactions
Epcoritamab + Thioridazine
Severity: Moderate
Epcoritamab and Thioridazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epcoritamab induces cytokine release that can temporarily suppress CYP enzyme activity. This may raise thioridazine concentrations, which is important given its dose-related QT prolongation.
What this interaction means in plain words
Epcoritamab and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Epcoritamab belongs to Oncology; Thioridazine belongs to Central Nervous System.
Why it happens
Cytokine-mediated transient suppression of CYP450 enzymes increases substrate exposure.
What to do
Monitor for thioridazine adverse effects and ECG changes around the first doses and during any cytokine release syndrome. Consider a dose reduction or alternative agent.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Other interactions of Epcoritamab
- Epcoritamab + Ergotamine Major
- Epcoritamab + Pimozide Major
- Bendamustine + Epcoritamab Moderate
- Carbamazepine + Epcoritamab Moderate
- Clomipramine + Epcoritamab Moderate
- Clozapine + Epcoritamab Moderate
Frequently asked questions
Can I take Epcoritamab with Thioridazine?
MediHelp rates the interaction as moderate. Epcoritamab and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epcoritamab induces cytokine release that can temporarily suppress CYP enzyme activity. This may raise thioridazine concentrations, which is important given its dose-related QT prolongation.
How serious is the interaction between Epcoritamab and Thioridazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for thioridazine adverse effects and ECG changes around the first doses and during any cytokine release syndrome. Consider a dose reduction or alternative agent.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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