Drug interactions
Ephedrine + Hydrochlorothiazide-lisinopril
Severity: Moderate
Ephedrine and Hydrochlorothiazide-lisinopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ephedrine has beta-adrenergic activity that can lower serum potassium modestly, adding to thiazide-induced potassium loss. It also raises blood pressure and may blunt the antihypertensive effect of the combination product. The clinical impact is usually modest.
What this interaction means in plain words
Ephedrine and Hydrochlorothiazide-lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ephedrine belongs to Cardiovascular; Hydrochlorothiazide-lisinopril belongs to Cardiovascular.
Why it happens
Beta-2 mediated cellular potassium uptake plus renal potassium wasting from thiazide; sympathomimetic pressor effect opposes antihypertensives.
What to do
Monitor blood pressure and serum potassium if ephedrine is used repeatedly or at high doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Other interactions of Ephedrine
- Ephedrine + Isocarboxazid Contraindicated
- Ephedrine + Phenelzine Contraindicated
- Ephedrine + Procarbazine Contraindicated
- Ephedrine + Rasagiline Contraindicated
- Ephedrine + Selegiline Contraindicated
- Ephedrine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Ephedrine with Hydrochlorothiazide-lisinopril?
MediHelp rates the interaction as moderate. Ephedrine and Hydrochlorothiazide-lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ephedrine has beta-adrenergic activity that can lower serum potassium modestly, adding to thiazide-induced potassium loss. It also raises blood pressure and may blunt the antihypertensive effect of the combination product. The clinical impact is usually modest.
How serious is the interaction between Ephedrine and Hydrochlorothiazide-lisinopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and serum potassium if ephedrine is used repeatedly or at high doses.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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