Drug interactions
Ephedrine + Hydromorphone
Severity: Minor
Ephedrine and Hydromorphone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ephedrine is a sympathomimetic that may offset some opioid-induced drowsiness and hypotension. This is not a harmful interaction, but stimulant effects may mask sedation.
What this interaction means in plain words
Ephedrine and Hydromorphone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ephedrine belongs to Cardiovascular; Hydromorphone belongs to Musculoskeletal.
Why it happens
Opposing pharmacodynamic effects on CNS arousal and blood pressure.
What to do
Judge opioid dosing by respiratory rate and pain control rather than alertness alone.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydromorphone
- Alvimopan + Hydromorphone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Hydromorphone + Isocarboxazid Contraindicated
- Hydromorphone + Olanzapine / samidorphan Contraindicated
- Hydromorphone + Phenelzine Contraindicated
- Hydromorphone + Tranylcypromine Contraindicated
Other interactions of Ephedrine
- Ephedrine + Isocarboxazid Contraindicated
- Ephedrine + Phenelzine Contraindicated
- Ephedrine + Procarbazine Contraindicated
- Ephedrine + Rasagiline Contraindicated
- Ephedrine + Selegiline Contraindicated
- Ephedrine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Ephedrine with Hydromorphone?
MediHelp rates the interaction as minor. Ephedrine and Hydromorphone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ephedrine is a sympathomimetic that may offset some opioid-induced drowsiness and hypotension. This is not a harmful interaction, but stimulant effects may mask sedation.
How serious is the interaction between Ephedrine and Hydromorphone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Judge opioid dosing by respiratory rate and pain control rather than alertness alone.
What other medicines interact with Hydromorphone?
MediHelp also lists interactions of Hydromorphone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydromorphone page.
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