Drug interactions
Ephedrine + Perphenazine
Severity: Moderate
Ephedrine and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perphenazine's alpha-blockade can blunt the pressor response to ephedrine, and ephedrine's stimulant effects oppose perphenazine's sedation. Ephedrine may also add to cardiac stimulation and arrhythmia risk in predisposed patients.
What this interaction means in plain words
Ephedrine and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ephedrine belongs to Cardiovascular; Perphenazine belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism through alpha-adrenergic blockade versus sympathomimetic activity.
What to do
Monitor blood pressure and heart rate and titrate ephedrine to effect. Use a direct-acting vasopressor if the response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Other interactions of Ephedrine
- Ephedrine + Isocarboxazid Contraindicated
- Ephedrine + Phenelzine Contraindicated
- Ephedrine + Procarbazine Contraindicated
- Ephedrine + Rasagiline Contraindicated
- Ephedrine + Selegiline Contraindicated
- Ephedrine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Ephedrine with Perphenazine?
MediHelp rates the interaction as moderate. Ephedrine and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Perphenazine's alpha-blockade can blunt the pressor response to ephedrine, and ephedrine's stimulant effects oppose perphenazine's sedation. Ephedrine may also add to cardiac stimulation and arrhythmia risk in predisposed patients.
How serious is the interaction between Ephedrine and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate and titrate ephedrine to effect. Use a direct-acting vasopressor if the response is inadequate.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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