Drug interactions
Epinephrine + Solriamfetol
Severity: Moderate
Epinephrine and Solriamfetol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Solriamfetol inhibits dopamine and norepinephrine reuptake and can raise blood pressure and heart rate. Combining it with epinephrine may amplify these cardiovascular effects, which matters in patients with hypertension or heart disease.
What this interaction means in plain words
Epinephrine and Solriamfetol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Epinephrine belongs to Endocrine; Solriamfetol belongs to Central Nervous System.
Why it happens
Additive pressor and chronotropic effects from reuptake inhibition of catecholamines plus direct adrenergic receptor agonism.
What to do
Monitor blood pressure and heart rate when epinephrine is used, including epinephrine in local anesthetics, and reduce the epinephrine dose where feasible. Review solriamfetol dose if hypertension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Other interactions of Solriamfetol
- Isocarboxazid + Solriamfetol Contraindicated
- Linezolid + Solriamfetol Contraindicated
- Phenelzine + Solriamfetol Contraindicated
- Procarbazine + Solriamfetol Contraindicated
- Rasagiline + Solriamfetol Contraindicated
- Safinamide + Solriamfetol Contraindicated
Frequently asked questions
Can I take Epinephrine with Solriamfetol?
MediHelp rates the interaction as moderate. Epinephrine and Solriamfetol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Solriamfetol inhibits dopamine and norepinephrine reuptake and can raise blood pressure and heart rate. Combining it with epinephrine may amplify these cardiovascular effects, which matters in patients with hypertension or heart disease.
How serious is the interaction between Epinephrine and Solriamfetol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when epinephrine is used, including epinephrine in local anesthetics, and reduce the epinephrine dose where feasible. Review solriamfetol dose if hypertension develops.
What other medicines interact with Epinephrine?
MediHelp also lists interactions of Epinephrine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Epinephrine page.
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