Drug interactions
Epinephrine + Vasopressin
Severity: Minor
Epinephrine and Vasopressin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epinephrine and vasopressin are both vasopressors and are often used together in shock or cardiac arrest. Their pressor effects are generally additive or complementary, not antagonistic, so the legacy claim of reduced vasopressin effect is not supported. Additive tachyarrhythmia or ischemia risk is possible at high doses.
What this interaction means in plain words
Epinephrine and Vasopressin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Epinephrine belongs to Endocrine; Vasopressin belongs to Endocrine.
Why it happens
Additive vasoconstriction through adrenergic receptors and vasopressin V1 receptors; no true antagonism established.
What to do
When used together, titrate each agent to blood pressure and monitor ECG for arrhythmia and signs of peripheral or myocardial ischemia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Other interactions of Vasopressin
- Carbamazepine + Vasopressin Moderate
- Clomipramine + Vasopressin Moderate
- Clozapine + Vasopressin Moderate
- Foscarnet + Vasopressin Moderate
- Haloperidol + Vasopressin Moderate
- Ibuprofen + Vasopressin Moderate
Frequently asked questions
Can I take Epinephrine with Vasopressin?
MediHelp rates the interaction as minor. Epinephrine and Vasopressin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Epinephrine and vasopressin are both vasopressors and are often used together in shock or cardiac arrest. Their pressor effects are generally additive or complementary, not antagonistic, so the legacy claim of reduced vasopressin effect is not supported. Additive tachyarrhythmia or ischemia risk is possible at high doses.
How serious is the interaction between Epinephrine and Vasopressin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: When used together, titrate each agent to blood pressure and monitor ECG for arrhythmia and signs of peripheral or myocardial ischemia.
What other medicines interact with Epinephrine?
MediHelp also lists interactions of Epinephrine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Epinephrine page.
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