Drug interactions
Clomipramine + Vasopressin
Severity: Moderate
Clomipramine and Vasopressin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants can cause hyponatremia through SIADH, which may be worsened by vasopressin's antidiuretic action. Vasopressin also has pressor effects that may be relevant in patients with cardiac disease.
What this interaction means in plain words
Clomipramine and Vasopressin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Vasopressin belongs to Endocrine.
Why it happens
Additive antidiuretic effect leading to water retention and hyponatremia.
What to do
Monitor serum sodium and fluid status, and watch for blood pressure and heart rhythm changes. Adjust therapy if hyponatremia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Vasopressin
- Carbamazepine + Vasopressin Moderate
- Clozapine + Vasopressin Moderate
- Foscarnet + Vasopressin Moderate
- Haloperidol + Vasopressin Moderate
- Ibuprofen + Vasopressin Moderate
- Indomethacin + Vasopressin Moderate
Frequently asked questions
Can I take Clomipramine with Vasopressin?
MediHelp rates the interaction as moderate. Clomipramine and Vasopressin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclic antidepressants can cause hyponatremia through SIADH, which may be worsened by vasopressin's antidiuretic action. Vasopressin also has pressor effects that may be relevant in patients with cardiac disease.
How serious is the interaction between Clomipramine and Vasopressin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum sodium and fluid status, and watch for blood pressure and heart rhythm changes. Adjust therapy if hyponatremia develops.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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