Drug interactions
Foscarnet + Vasopressin
Severity: Moderate
Foscarnet and Vasopressin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Foscarnet can cause nephrogenic diabetes insipidus, which may blunt the response to vasopressin. The pressor and antidiuretic effects may therefore be weaker than expected.
What this interaction means in plain words
Foscarnet and Vasopressin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Foscarnet belongs to Anti Virals; Vasopressin belongs to Endocrine.
Why it happens
Foscarnet-induced nephrogenic diabetes insipidus reduces renal responsiveness to vasopressin, which may offset its antidiuretic effect.
What to do
Monitor blood pressure, urine output, and serum sodium, and titrate vasopressin to hemodynamic response. Watch for polyuria and for electrolyte disturbances caused by foscarnet.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vasopressin
- Carbamazepine + Vasopressin Moderate
- Clomipramine + Vasopressin Moderate
- Clozapine + Vasopressin Moderate
- Haloperidol + Vasopressin Moderate
- Ibuprofen + Vasopressin Moderate
- Indomethacin + Vasopressin Moderate
Other interactions of Foscarnet
- Cidofovir + Foscarnet Contraindicated
- Foscarnet + Pimozide Contraindicated
- Foscarnet + Thioridazine Contraindicated
- Foscarnet + Vandetanib Contraindicated
- Adagrasib + Foscarnet Major
- Adefovir + Foscarnet Major
Frequently asked questions
Can I take Foscarnet with Vasopressin?
MediHelp rates the interaction as moderate. Foscarnet and Vasopressin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Foscarnet can cause nephrogenic diabetes insipidus, which may blunt the response to vasopressin. The pressor and antidiuretic effects may therefore be weaker than expected.
How serious is the interaction between Foscarnet and Vasopressin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, urine output, and serum sodium, and titrate vasopressin to hemodynamic response. Watch for polyuria and for electrolyte disturbances caused by foscarnet.
What other medicines interact with Vasopressin?
MediHelp also lists interactions of Vasopressin with, for example, Carbamazepine, Clomipramine, Clozapine. The full list is on the Vasopressin page.
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