Drug interactions
Haloperidol + Vasopressin
Severity: Moderate
Haloperidol and Vasopressin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Haloperidol has been associated with SIADH, which can add to the antidiuretic and pressor activity of vasopressin. The result may be a stronger vasopressor effect together with water retention and hyponatremia.
What this interaction means in plain words
Haloperidol and Vasopressin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Haloperidol belongs to Central Nervous System; Vasopressin belongs to Endocrine.
Why it happens
Additive effects on water retention and vasopressin activity, as haloperidol can promote inappropriate ADH secretion.
What to do
Monitor blood pressure and serum sodium during vasopressin therapy and adjust the dose to the hemodynamic response. Reassess the need for haloperidol if hyponatremia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vasopressin
- Carbamazepine + Vasopressin Moderate
- Clomipramine + Vasopressin Moderate
- Clozapine + Vasopressin Moderate
- Foscarnet + Vasopressin Moderate
- Ibuprofen + Vasopressin Moderate
- Indomethacin + Vasopressin Moderate
Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Haloperidol with Vasopressin?
MediHelp rates the interaction as moderate. Haloperidol and Vasopressin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Haloperidol has been associated with SIADH, which can add to the antidiuretic and pressor activity of vasopressin. The result may be a stronger vasopressor effect together with water retention and hyponatremia.
How serious is the interaction between Haloperidol and Vasopressin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and serum sodium during vasopressin therapy and adjust the dose to the hemodynamic response. Reassess the need for haloperidol if hyponatremia develops.
What other medicines interact with Vasopressin?
MediHelp also lists interactions of Vasopressin with, for example, Carbamazepine, Clomipramine, Clozapine. The full list is on the Vasopressin page.
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