Drug interactions
Clozapine + Vasopressin
Severity: Moderate
Clozapine and Vasopressin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clozapine has been linked to diabetes insipidus and polyuria in some cases, which could reduce the response to vasopressin. The pressor effect may be lower than expected.
What this interaction means in plain words
Clozapine and Vasopressin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Vasopressin belongs to Endocrine.
Why it happens
Clozapine may impair vasopressin-mediated water handling, though the mechanism is not well established.
What to do
Monitor blood pressure, urine output, and serum sodium during vasopressin therapy, and adjust the dose to the observed hemodynamic response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vasopressin
- Carbamazepine + Vasopressin Moderate
- Clomipramine + Vasopressin Moderate
- Foscarnet + Vasopressin Moderate
- Haloperidol + Vasopressin Moderate
- Ibuprofen + Vasopressin Moderate
- Indomethacin + Vasopressin Moderate
Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Clozapine with Vasopressin?
MediHelp rates the interaction as moderate. Clozapine and Vasopressin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clozapine has been linked to diabetes insipidus and polyuria in some cases, which could reduce the response to vasopressin. The pressor effect may be lower than expected.
How serious is the interaction between Clozapine and Vasopressin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, urine output, and serum sodium during vasopressin therapy, and adjust the dose to the observed hemodynamic response.
What other medicines interact with Vasopressin?
MediHelp also lists interactions of Vasopressin with, for example, Carbamazepine, Clomipramine, Foscarnet. The full list is on the Vasopressin page.
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