Drug interactions
Carbamazepine + Vasopressin
Severity: Moderate
Carbamazepine and Vasopressin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine has antidiuretic activity and can promote water retention and hyponatremia. Combined with vasopressin, which also causes water retention, the antidiuretic effect may be amplified.
What this interaction means in plain words
Carbamazepine and Vasopressin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbamazepine belongs to Central Nervous System; Vasopressin belongs to Endocrine.
Why it happens
Additive antidiuretic effects, with carbamazepine enhancing renal responsiveness to antidiuretic hormone.
What to do
Monitor serum sodium and fluid status when vasopressin is given to a patient on carbamazepine. Reduce or stop the combination if hyponatremia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Other interactions of Vasopressin
- Clomipramine + Vasopressin Moderate
- Clozapine + Vasopressin Moderate
- Foscarnet + Vasopressin Moderate
- Haloperidol + Vasopressin Moderate
- Ibuprofen + Vasopressin Moderate
- Indomethacin + Vasopressin Moderate
Frequently asked questions
Can I take Carbamazepine with Vasopressin?
MediHelp rates the interaction as moderate. Carbamazepine and Vasopressin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine has antidiuretic activity and can promote water retention and hyponatremia. Combined with vasopressin, which also causes water retention, the antidiuretic effect may be amplified.
How serious is the interaction between Carbamazepine and Vasopressin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum sodium and fluid status when vasopressin is given to a patient on carbamazepine. Reduce or stop the combination if hyponatremia develops.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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