Drug interactions
Eprosartan-hydrochlorothiazide + Toremifene
Severity: Moderate
Eprosartan-hydrochlorothiazide and Toremifene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Toremifene can cause hypercalcemia in patients with bone metastases, and thiazide diuretics reduce urinary calcium excretion. Together they may raise serum calcium more than either alone.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and Toremifene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eprosartan-hydrochlorothiazide belongs to Cardiovascular; Toremifene belongs to Endocrine.
Why it happens
Thiazides enhance distal tubular calcium reabsorption, adding to toremifene-associated hypercalcemia.
What to do
Monitor serum calcium regularly, particularly early in toremifene treatment, and consider replacing the thiazide if hypercalcemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Other interactions of Toremifene
- Amiodarone + Toremifene Contraindicated
- Dronedarone + Toremifene Contraindicated
- Nilotinib + Toremifene Contraindicated
- Pimozide + Toremifene Contraindicated
- Quinidine + Toremifene Contraindicated
- Ribociclib + Toremifene Contraindicated
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with Toremifene?
MediHelp rates the interaction as moderate. Eprosartan-hydrochlorothiazide and Toremifene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Toremifene can cause hypercalcemia in patients with bone metastases, and thiazide diuretics reduce urinary calcium excretion. Together they may raise serum calcium more than either alone.
How serious is the interaction between Eprosartan-hydrochlorothiazide and Toremifene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium regularly, particularly early in toremifene treatment, and consider replacing the thiazide if hypercalcemia develops.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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