Drug interactions
Erdafitinib + Posaconazole
Severity: Major
Erdafitinib and Posaconazole: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole can increase erdafitinib exposure, raising the risk of hyperphosphatemia, ocular toxicity, stomatitis and skin or nail effects.
What this interaction means in plain words
Erdafitinib and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Erdafitinib belongs to Oncology; Posaconazole belongs to Anti Fungals.
Why it happens
Strong CYP3A4 inhibition reduces erdafitinib clearance.
What to do
Avoid if possible. If needed, monitor closely for toxicity and reduce the erdafitinib dose, then reconsider dose escalation after the inhibitor is stopped.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Erdafitinib
Frequently asked questions
Can I take Erdafitinib with Posaconazole?
MediHelp rates the interaction as major. Erdafitinib and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Posaconazole can increase erdafitinib exposure, raising the risk of hyperphosphatemia, ocular toxicity, stomatitis and skin or nail effects.
How serious is the interaction between Erdafitinib and Posaconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If needed, monitor closely for toxicity and reduce the erdafitinib dose, then reconsider dose escalation after the inhibitor is stopped.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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