Drug interactions
Ergocalciferol + Orlistat
Severity: Moderate
Ergocalciferol and Orlistat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Orlistat blocks fat digestion and reduces absorption of fat-soluble vitamins, including vitamin D. Long-term use can lower vitamin D levels.
What this interaction means in plain words
Ergocalciferol and Orlistat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ergocalciferol belongs to Musculoskeletal; Orlistat belongs to Miscellaneous.
Why it happens
Inhibition of gastrointestinal lipases reduces dietary fat and fat-soluble vitamin absorption.
What to do
Take vitamin D at least 2 hours before or after orlistat, ideally at bedtime. Monitor 25-hydroxyvitamin D levels during long-term therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ergocalciferol
- Aluminum hydroxide + Ergocalciferol Moderate
- Calcium acetate + Ergocalciferol Moderate
- Calcium carbonate + Ergocalciferol Moderate
- Calcium chloride + Ergocalciferol Moderate
- Calcium citrate + Ergocalciferol Moderate
- Calcium gluconate + Ergocalciferol Moderate
Other interactions of Orlistat
- Cyclosporin + Orlistat Major
- Orlistat + Triheptanoin Major
- Amiodarone + Orlistat Moderate
- Beta carotene + Orlistat Moderate
- Carbamazepine + Orlistat Moderate
- Cholecalciferol + Orlistat Moderate
Frequently asked questions
Can I take Ergocalciferol with Orlistat?
MediHelp rates the interaction as moderate. Ergocalciferol and Orlistat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Orlistat blocks fat digestion and reduces absorption of fat-soluble vitamins, including vitamin D. Long-term use can lower vitamin D levels.
How serious is the interaction between Ergocalciferol and Orlistat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take vitamin D at least 2 hours before or after orlistat, ideally at bedtime. Monitor 25-hydroxyvitamin D levels during long-term therapy.
What other medicines interact with Ergocalciferol?
MediHelp also lists interactions of Ergocalciferol with, for example, Aluminum hydroxide, Calcium acetate, Calcium carbonate. The full list is on the Ergocalciferol page.
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