Drug interactions
Ergotamine + Lemborexant
Severity: Minor
Ergotamine and Lemborexant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ergotamine is not a recognized CYP3A4 inhibitor, so any increase in lemborexant exposure is likely small and unproven. If it occurs, it could increase somnolence and next-day impairment.
What this interaction means in plain words
Ergotamine and Lemborexant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ergotamine belongs to Central Nervous System; Lemborexant belongs to Central Nervous System.
Why it happens
Theoretical weak competition for CYP3A4 metabolism of lemborexant.
What to do
Monitor for excessive sedation and next-day drowsiness. Reduce the lemborexant dose if impairment occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Other interactions of Lemborexant
Frequently asked questions
Can I take Ergotamine with Lemborexant?
MediHelp rates the interaction as minor. Ergotamine and Lemborexant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ergotamine is not a recognized CYP3A4 inhibitor, so any increase in lemborexant exposure is likely small and unproven. If it occurs, it could increase somnolence and next-day impairment.
How serious is the interaction between Ergotamine and Lemborexant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and next-day drowsiness. Reduce the lemborexant dose if impairment occurs.
What other medicines interact with Ergotamine?
MediHelp also lists interactions of Ergotamine with, for example, Almotriptan, Atazanavir, Clarithromycin. The full list is on the Ergotamine page.
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