Drug interactions
Ergotamine + Linezolid
Severity: Major
Ergotamine and Linezolid: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Linezolid's MAO inhibition may add to ergotamine's serotonergic and vasoconstrictive effects. This may cause serotonin toxicity or hypertensive and vasospastic reactions.
What this interaction means in plain words
Ergotamine and Linezolid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ergotamine belongs to Central Nervous System; Linezolid belongs to Anti Bacterial.
Why it happens
Additive serotonergic and pressor effects from MAO inhibition and ergot agonism at serotonin receptors.
What to do
Avoid using together and select an alternative antibiotic or migraine therapy. If unavoidable, monitor blood pressure, perfusion and signs of serotonin toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Frequently asked questions
Can I take Ergotamine with Linezolid?
MediHelp rates the interaction as major. Ergotamine and Linezolid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Linezolid's MAO inhibition may add to ergotamine's serotonergic and vasoconstrictive effects. This may cause serotonin toxicity or hypertensive and vasospastic reactions.
How serious is the interaction between Ergotamine and Linezolid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using together and select an alternative antibiotic or migraine therapy. If unavoidable, monitor blood pressure, perfusion and signs of serotonin toxicity.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
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