Drug interactions
Ergotamine + Pexidartinib
Severity: Moderate
Ergotamine and Pexidartinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pexidartinib is a moderate CYP3A inducer and may lower ergotamine exposure, leading to therapeutic failure. Labeling advises dose adjustment of sensitive CYP3A substrates if coadministered.
What this interaction means in plain words
Ergotamine and Pexidartinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ergotamine belongs to Central Nervous System; Pexidartinib belongs to Oncology.
Why it happens
Pexidartinib induces CYP3A4, accelerating ergotamine metabolism.
What to do
Monitor for reduced antimigraine effect and prefer a non-ergot alternative. Do not exceed labeled ergotamine doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Other interactions of Pexidartinib
Frequently asked questions
Can I take Ergotamine with Pexidartinib?
MediHelp rates the interaction as moderate. Ergotamine and Pexidartinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pexidartinib is a moderate CYP3A inducer and may lower ergotamine exposure, leading to therapeutic failure. Labeling advises dose adjustment of sensitive CYP3A substrates if coadministered.
How serious is the interaction between Ergotamine and Pexidartinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced antimigraine effect and prefer a non-ergot alternative. Do not exceed labeled ergotamine doses.
What other medicines interact with Ergotamine?
MediHelp also lists interactions of Ergotamine with, for example, Almotriptan, Atazanavir, Clarithromycin. The full list is on the Ergotamine page.
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