Drug interactions
Ergotamine + Quetiapine
Severity: Moderate
Ergotamine and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ergotamine is a serotonergic agent and quetiapine has serotonin and dopamine receptor activity, so theoretical additive serotonergic effects and neuroleptic-related toxicity are described. Quetiapine is a CYP3A4 substrate but its effect on ergotamine is not established; the main concern is pharmacodynamic.
What this interaction means in plain words
Ergotamine and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ergotamine belongs to Central Nervous System; Quetiapine belongs to Central Nervous System.
Why it happens
Possible additive serotonergic and dopaminergic effects; no well-established pharmacokinetic mechanism.
What to do
Monitor for signs of serotonin toxicity such as agitation, tremor, hyperthermia and clonus, and for neuroleptic malignant syndrome. Limit ergotamine to the lowest effective dose and frequency.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Frequently asked questions
Can I take Ergotamine with Quetiapine?
MediHelp rates the interaction as moderate. Ergotamine and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ergotamine is a serotonergic agent and quetiapine has serotonin and dopamine receptor activity, so theoretical additive serotonergic effects and neuroleptic-related toxicity are described. Quetiapine is a CYP3A4 substrate but its effect on ergotamine is not established; the main concern is pharmacodynamic.
How serious is the interaction between Ergotamine and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of serotonin toxicity such as agitation, tremor, hyperthermia and clonus, and for neuroleptic malignant syndrome. Limit ergotamine to the lowest effective dose and frequency.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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