Drug interactions
Ergotamine + Ustekinumab
Severity: Minor
Ergotamine and Ustekinumab: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ergotamine is a CYP3A4 substrate with a narrow margin of safety. Normalization of CYP3A4 activity after ustekinumab could theoretically reduce ergotamine exposure, though no clinical data show this.
What this interaction means in plain words
Ergotamine and Ustekinumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ergotamine belongs to Central Nervous System; Ustekinumab belongs to Gastrointestinal Tract.
Why it happens
Theoretical reversal of cytokine-mediated CYP3A4 suppression.
What to do
Monitor for changes in headache control or ergotism symptoms when ustekinumab is started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ustekinumab
- Bcg vaccine live + Ustekinumab Contraindicated
- Typhoid vaccine live + Ustekinumab Contraindicated
- Adalimumab + Ustekinumab Major
- Adenovirus types 4 and 7 live + Ustekinumab Major
- Alefacept + Ustekinumab Major
- Anakinra + Ustekinumab Major
Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Frequently asked questions
Can I take Ergotamine with Ustekinumab?
MediHelp rates the interaction as minor. Ergotamine and Ustekinumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ergotamine is a CYP3A4 substrate with a narrow margin of safety. Normalization of CYP3A4 activity after ustekinumab could theoretically reduce ergotamine exposure, though no clinical data show this.
How serious is the interaction between Ergotamine and Ustekinumab?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for changes in headache control or ergotism symptoms when ustekinumab is started or stopped.
What other medicines interact with Ustekinumab?
MediHelp also lists interactions of Ustekinumab with, for example, Bcg vaccine live, Typhoid vaccine live, Adalimumab. The full list is on the Ustekinumab page.
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