Drug interactions
Ergotamine + Vonoprazan
Severity: Moderate
Ergotamine and Vonoprazan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vonoprazan is a weak CYP3A inhibitor and may slightly raise ergotamine concentrations. The effect is probably small but ergotamine toxicity is serious.
What this interaction means in plain words
Ergotamine and Vonoprazan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ergotamine belongs to Central Nervous System; Vonoprazan belongs to Gastrointestinal Tract.
Why it happens
Weak CYP3A4 inhibition by vonoprazan reduces ergotamine clearance.
What to do
Monitor for peripheral vasospasm symptoms, nausea and paresthesia. Limit ergotamine dosing frequency and consider alternatives if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Other interactions of Vonoprazan
- Amobarbital + Vonoprazan Major
- Apalutamide + Vonoprazan Major
- Atazanavir + Vonoprazan Major
- Carbamazepine + Vonoprazan Major
- Erlotinib + Vonoprazan Major
- Phenytoin + Vonoprazan Major
Frequently asked questions
Can I take Ergotamine with Vonoprazan?
MediHelp rates the interaction as moderate. Ergotamine and Vonoprazan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vonoprazan is a weak CYP3A inhibitor and may slightly raise ergotamine concentrations. The effect is probably small but ergotamine toxicity is serious.
How serious is the interaction between Ergotamine and Vonoprazan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for peripheral vasospasm symptoms, nausea and paresthesia. Limit ergotamine dosing frequency and consider alternatives if symptoms occur.
What other medicines interact with Ergotamine?
MediHelp also lists interactions of Ergotamine with, for example, Almotriptan, Atazanavir, Clarithromycin. The full list is on the Ergotamine page.
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