Drug interactions
Ergotamine + Ziprasidone
Severity: Moderate
Ergotamine and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ergotamine has serotonergic and vasoconstrictive actions, and combined with an antipsychotic it may rarely contribute to serotonin toxicity or neuroleptic malignant syndrome. The main concern is that this risk is largely theoretical and based on mechanism, rather than strong clinical evidence.
What this interaction means in plain words
Ergotamine and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ergotamine belongs to Central Nervous System; Ziprasidone belongs to Central Nervous System.
Why it happens
Possible additive serotonergic activity combined with dopamine receptor blockade.
What to do
Monitor for signs of serotonin toxicity such as agitation, tremor, hyperthermia and clonus, and for neuroleptic malignant syndrome. Use the lowest effective ergotamine dose and stop if symptoms emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Frequently asked questions
Can I take Ergotamine with Ziprasidone?
MediHelp rates the interaction as moderate. Ergotamine and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ergotamine has serotonergic and vasoconstrictive actions, and combined with an antipsychotic it may rarely contribute to serotonin toxicity or neuroleptic malignant syndrome. The main concern is that this risk is largely theoretical and based on mechanism, rather than strong clinical evidence.
How serious is the interaction between Ergotamine and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of serotonin toxicity such as agitation, tremor, hyperthermia and clonus, and for neuroleptic malignant syndrome. Use the lowest effective ergotamine dose and stop if symptoms emerge.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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