Drug interactions
Eribulin + Leuprolide
Severity: Moderate
Eribulin and Leuprolide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eribulin can prolong the QT interval, and androgen deprivation therapy with leuprolide may also prolong it. Together they may raise the risk of QT prolongation and torsades de pointes, especially with electrolyte disturbances.
What this interaction means in plain words
Eribulin and Leuprolide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eribulin belongs to Oncology; Leuprolide belongs to Endocrine.
Why it happens
Additive QT interval prolongation, via androgen deprivation (leuprolide) and direct effects of eribulin.
What to do
Obtain an ECG at baseline and monitor it periodically, and correct potassium and magnesium before and during eribulin treatment. Avoid additional QT-prolonging drugs where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Leuprolide
- Leuprolide + Pimozide Contraindicated
- Leuprolide + Thioridazine Contraindicated
- Amisulpride + Leuprolide Major
- Arsenic trioxide + Leuprolide Major
- Artemether / lumefantrine + Leuprolide Major
- Disopyramide + Leuprolide Major
Other interactions of Eribulin
Frequently asked questions
Can I take Eribulin with Leuprolide?
MediHelp rates the interaction as moderate. Eribulin and Leuprolide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eribulin can prolong the QT interval, and androgen deprivation therapy with leuprolide may also prolong it. Together they may raise the risk of QT prolongation and torsades de pointes, especially with electrolyte disturbances.
How serious is the interaction between Eribulin and Leuprolide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG at baseline and monitor it periodically, and correct potassium and magnesium before and during eribulin treatment. Avoid additional QT-prolonging drugs where possible.
What other medicines interact with Leuprolide?
MediHelp also lists interactions of Leuprolide with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Leuprolide page.
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