Drug interactions
Eribulin + Prochlorperazine
Severity: Moderate
Eribulin and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eribulin can prolong the QT interval and prochlorperazine has similar potential, so combined use may raise arrhythmia risk. Risk is higher with electrolyte abnormalities, heart failure or bradycardia.
What this interaction means in plain words
Eribulin and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eribulin belongs to Oncology; Prochlorperazine belongs to Central Nervous System.
Why it happens
Additive QT interval prolongation.
What to do
Monitor ECG and electrolytes, correcting hypokalemia and hypomagnesemia. Consider a non-QT-prolonging antiemetic in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Eribulin
Frequently asked questions
Can I take Eribulin with Prochlorperazine?
MediHelp rates the interaction as moderate. Eribulin and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eribulin can prolong the QT interval and prochlorperazine has similar potential, so combined use may raise arrhythmia risk. Risk is higher with electrolyte abnormalities, heart failure or bradycardia.
How serious is the interaction between Eribulin and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes, correcting hypokalemia and hypomagnesemia. Consider a non-QT-prolonging antiemetic in high-risk patients.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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