Drug interactions
Eribulin + Toremifene
Severity: Major
Eribulin and Toremifene: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Toremifene prolongs the QT interval in a dose-dependent manner and is contraindicated in patients at risk of QT prolongation. Eribulin may add to this effect and raise the risk of torsades de pointes.
What this interaction means in plain words
Eribulin and Toremifene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eribulin belongs to Oncology; Toremifene belongs to Endocrine.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Avoid the combination; consider an alternative endocrine agent such as an aromatase inhibitor where appropriate. If unavoidable, monitor ECG and electrolytes closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Eribulin
Other interactions of Toremifene
- Amiodarone + Toremifene Contraindicated
- Dronedarone + Toremifene Contraindicated
- Nilotinib + Toremifene Contraindicated
- Pimozide + Toremifene Contraindicated
- Quinidine + Toremifene Contraindicated
- Ribociclib + Toremifene Contraindicated
Frequently asked questions
Can I take Eribulin with Toremifene?
MediHelp rates the interaction as major. Eribulin and Toremifene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Toremifene prolongs the QT interval in a dose-dependent manner and is contraindicated in patients at risk of QT prolongation. Eribulin may add to this effect and raise the risk of torsades de pointes.
How serious is the interaction between Eribulin and Toremifene?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; consider an alternative endocrine agent such as an aromatase inhibitor where appropriate. If unavoidable, monitor ECG and electrolytes closely.
What other medicines interact with Eribulin?
MediHelp also lists interactions of Eribulin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Eribulin page.
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