Drug interactions
Erlotinib + Tucatinib
Severity: Moderate
Erlotinib and Tucatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib is a CYP3A inhibitor and may increase exposure to erlotinib. This could heighten erlotinib toxicity.
What this interaction means in plain words
Erlotinib and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erlotinib belongs to Oncology; Tucatinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4 metabolism of erlotinib by tucatinib.
What to do
Avoid if possible. If used together, monitor for erlotinib adverse effects and reduce the dose in 50 mg steps for severe toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erlotinib
- Amobarbital + Erlotinib Major
- Apalutamide + Erlotinib Major
- Carbamazepine + Erlotinib Major
- Cobicistat + Erlotinib Major
- Darunavir + Erlotinib Major
- Dexlansoprazole + Erlotinib Major
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Erlotinib with Tucatinib?
MediHelp rates the interaction as moderate. Erlotinib and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tucatinib is a CYP3A inhibitor and may increase exposure to erlotinib. This could heighten erlotinib toxicity.
How serious is the interaction between Erlotinib and Tucatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If used together, monitor for erlotinib adverse effects and reduce the dose in 50 mg steps for severe toxicity.
What other medicines interact with Erlotinib?
MediHelp also lists interactions of Erlotinib with, for example, Amobarbital, Apalutamide, Carbamazepine. The full list is on the Erlotinib page.
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