Drug interactions
Ertugliflozin + Glibenclamide
Severity: Moderate
Ertugliflozin and Glibenclamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ertugliflozin lowers blood glucose independently of insulin and increases hypoglycemia risk when combined with sulfonylureas such as glyburide.
What this interaction means in plain words
Ertugliflozin and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ertugliflozin belongs to Endocrine; Glibenclamide belongs to Endocrine.
Why it happens
Additive glucose-lowering from sulfonylurea insulin secretion and SGLT2-mediated urinary glucose loss.
What to do
Consider lowering the glyburide dose when ertugliflozin is added and monitor for hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Other interactions of Ertugliflozin
- Chlorpropamide + Ertugliflozin Moderate
- Ertugliflozin + Gliclazide Moderate
- Ertugliflozin + Glimepiride Moderate
- Ertugliflozin + Glimepiride-pioglitazone Moderate
- Ertugliflozin + Glipizide Moderate
- Ertugliflozin + Glipizide-metformin Moderate
Frequently asked questions
Can I take Ertugliflozin with Glibenclamide?
MediHelp rates the interaction as moderate. Ertugliflozin and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ertugliflozin lowers blood glucose independently of insulin and increases hypoglycemia risk when combined with sulfonylureas such as glyburide.
How serious is the interaction between Ertugliflozin and Glibenclamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider lowering the glyburide dose when ertugliflozin is added and monitor for hypoglycemia.
What other medicines interact with Glibenclamide?
MediHelp also lists interactions of Glibenclamide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glibenclamide page.
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