Drug interactions
Ertugliflozin + Glipizide-metformin
Severity: Moderate
Ertugliflozin and Glipizide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ertugliflozin adds glucose-lowering activity to glipizide, an insulin secretagogue, so hypoglycemia is more likely. Volume depletion from the SGLT2 inhibitor may add further risk.
What this interaction means in plain words
Ertugliflozin and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ertugliflozin belongs to Endocrine; Glipizide-metformin belongs to Endocrine.
Why it happens
Additive pharmacodynamic glucose lowering, with sulfonylurea-driven insulin release unopposed by SGLT2-mediated glucosuria.
What to do
Consider lowering the glipizide dose when starting ertugliflozin and monitor blood glucose. Counsel the patient on recognizing hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ertugliflozin and Glipizide-metformin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Glipizide-metformin
Other interactions of Ertugliflozin
- Chlorpropamide + Ertugliflozin Moderate
- Ertugliflozin + Glibenclamide Moderate
- Ertugliflozin + Gliclazide Moderate
- Ertugliflozin + Glimepiride Moderate
- Ertugliflozin + Glimepiride-pioglitazone Moderate
- Ertugliflozin + Glipizide Moderate
Frequently asked questions
Can I take Ertugliflozin with Glipizide-metformin?
MediHelp rates the interaction as moderate. Ertugliflozin and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ertugliflozin adds glucose-lowering activity to glipizide, an insulin secretagogue, so hypoglycemia is more likely. Volume depletion from the SGLT2 inhibitor may add further risk.
How serious is the interaction between Ertugliflozin and Glipizide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider lowering the glipizide dose when starting ertugliflozin and monitor blood glucose. Counsel the patient on recognizing hypoglycemia.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
