Drug interactions
Ertugliflozin + Gliclazide
Severity: Moderate
Ertugliflozin and Gliclazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ertugliflozin together with gliclazide increases the risk of hypoglycemia because both lower glucose by different routes. This is described in SGLT2 inhibitor labeling.
What this interaction means in plain words
Ertugliflozin and Gliclazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ertugliflozin belongs to Endocrine; Gliclazide belongs to Endocrine.
Why it happens
Additive glucose lowering from glucosuria and sulfonylurea-stimulated insulin secretion.
What to do
Consider a lower gliclazide dose when adding ertugliflozin, and monitor glucose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Other interactions of Ertugliflozin
- Chlorpropamide + Ertugliflozin Moderate
- Ertugliflozin + Glibenclamide Moderate
- Ertugliflozin + Glimepiride Moderate
- Ertugliflozin + Glimepiride-pioglitazone Moderate
- Ertugliflozin + Glipizide Moderate
- Ertugliflozin + Glipizide-metformin Moderate
Frequently asked questions
Can I take Ertugliflozin with Gliclazide?
MediHelp rates the interaction as moderate. Ertugliflozin and Gliclazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ertugliflozin together with gliclazide increases the risk of hypoglycemia because both lower glucose by different routes. This is described in SGLT2 inhibitor labeling.
How serious is the interaction between Ertugliflozin and Gliclazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a lower gliclazide dose when adding ertugliflozin, and monitor glucose.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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