Drug interactions
Ertugliflozin + Glimepiride
Severity: Moderate
Ertugliflozin and Glimepiride: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ertugliflozin adds glucose lowering to that of glimepiride, increasing the risk of hypoglycemia. Sulfonylurea dose reduction may be needed.
What this interaction means in plain words
Ertugliflozin and Glimepiride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ertugliflozin belongs to Endocrine; Glimepiride belongs to Endocrine.
Why it happens
Additive glucose-lowering effects of SGLT2 inhibition and sulfonylurea-stimulated insulin secretion.
What to do
Consider reducing the glimepiride dose when starting ertugliflozin. Monitor blood glucose and educate the patient about hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glimepiride
Other interactions of Ertugliflozin
- Chlorpropamide + Ertugliflozin Moderate
- Ertugliflozin + Glibenclamide Moderate
- Ertugliflozin + Gliclazide Moderate
- Ertugliflozin + Glimepiride-pioglitazone Moderate
- Ertugliflozin + Glipizide Moderate
- Ertugliflozin + Glipizide-metformin Moderate
Frequently asked questions
Can I take Ertugliflozin with Glimepiride?
MediHelp rates the interaction as moderate. Ertugliflozin and Glimepiride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ertugliflozin adds glucose lowering to that of glimepiride, increasing the risk of hypoglycemia. Sulfonylurea dose reduction may be needed.
How serious is the interaction between Ertugliflozin and Glimepiride?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the glimepiride dose when starting ertugliflozin. Monitor blood glucose and educate the patient about hypoglycemia.
What other medicines interact with Glimepiride?
MediHelp also lists interactions of Glimepiride with, for example, Fluconazole, Insulin degludec-liraglutide, Insulin glargine-lixisenatide. The full list is on the Glimepiride page.
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