Drug interactions
Ertugliflozin + Glimepiride-pioglitazone
Severity: Moderate
Ertugliflozin and Glimepiride-pioglitazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ertugliflozin adds glucose-lowering through glycosuria to the effect of glimepiride, a sulfonylurea. The combination raises the risk of hypoglycemia, and pioglitazone adds a further modest contribution.
What this interaction means in plain words
Ertugliflozin and Glimepiride-pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ertugliflozin belongs to Endocrine; Glimepiride-pioglitazone belongs to Endocrine.
Why it happens
Additive pharmacodynamic glucose lowering between an SGLT2 inhibitor and insulin secretagogue or insulin sensitizer.
What to do
Consider reducing the glimepiride dose when ertugliflozin is added, and monitor blood glucose. Teach the patient to recognize hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glimepiride-pioglitazone
Other interactions of Ertugliflozin
- Chlorpropamide + Ertugliflozin Moderate
- Ertugliflozin + Glibenclamide Moderate
- Ertugliflozin + Gliclazide Moderate
- Ertugliflozin + Glimepiride Moderate
- Ertugliflozin + Glipizide Moderate
- Ertugliflozin + Glipizide-metformin Moderate
Frequently asked questions
Can I take Ertugliflozin with Glimepiride-pioglitazone?
MediHelp rates the interaction as moderate. Ertugliflozin and Glimepiride-pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ertugliflozin adds glucose-lowering through glycosuria to the effect of glimepiride, a sulfonylurea. The combination raises the risk of hypoglycemia, and pioglitazone adds a further modest contribution.
How serious is the interaction between Ertugliflozin and Glimepiride-pioglitazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the glimepiride dose when ertugliflozin is added, and monitor blood glucose. Teach the patient to recognize hypoglycemia.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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