Drug interactions
Chlorpropamide + Ertugliflozin
Severity: Moderate
Chlorpropamide and Ertugliflozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
SGLT2 inhibitors added to sulfonylureas increase the risk of hypoglycemia. Chlorpropamide has a long half-life, so hypoglycemia may be prolonged.
What this interaction means in plain words
Chlorpropamide and Ertugliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Ertugliflozin belongs to Endocrine.
Why it happens
Additive glucose lowering from insulin secretion by the sulfonylurea and urinary glucose excretion by ertugliflozin.
What to do
Consider reducing the chlorpropamide dose when ertugliflozin is started. Monitor blood glucose and counsel the patient on hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpropamide
Other interactions of Ertugliflozin
- Ertugliflozin + Glibenclamide Moderate
- Ertugliflozin + Gliclazide Moderate
- Ertugliflozin + Glimepiride Moderate
- Ertugliflozin + Glimepiride-pioglitazone Moderate
- Ertugliflozin + Glipizide Moderate
- Ertugliflozin + Glipizide-metformin Moderate
Frequently asked questions
Can I take Chlorpropamide with Ertugliflozin?
MediHelp rates the interaction as moderate. Chlorpropamide and Ertugliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. SGLT2 inhibitors added to sulfonylureas increase the risk of hypoglycemia. Chlorpropamide has a long half-life, so hypoglycemia may be prolonged.
How serious is the interaction between Chlorpropamide and Ertugliflozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the chlorpropamide dose when ertugliflozin is started. Monitor blood glucose and counsel the patient on hypoglycemia.
What other medicines interact with Chlorpropamide?
MediHelp also lists interactions of Chlorpropamide with, for example, Ethanol, Exenatide, Insulin degludec-insulin aspart. The full list is on the Chlorpropamide page.
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