Drug interactions
Ertugliflozin + Glipizide
Severity: Moderate
Ertugliflozin and Glipizide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adding ertugliflozin to a sulfonylurea increases the risk of hypoglycemia. This is described in product labeling.
What this interaction means in plain words
Ertugliflozin and Glipizide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ertugliflozin belongs to Endocrine; Glipizide belongs to Endocrine.
Why it happens
Additive glucose lowering from SGLT2-mediated glucosuria plus sulfonylurea-stimulated insulin secretion.
What to do
Consider a lower glipizide dose when ertugliflozin is added. Monitor blood glucose and educate on hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide
Other interactions of Ertugliflozin
- Chlorpropamide + Ertugliflozin Moderate
- Ertugliflozin + Glibenclamide Moderate
- Ertugliflozin + Gliclazide Moderate
- Ertugliflozin + Glimepiride Moderate
- Ertugliflozin + Glimepiride-pioglitazone Moderate
- Ertugliflozin + Glipizide-metformin Moderate
Frequently asked questions
Can I take Ertugliflozin with Glipizide?
MediHelp rates the interaction as moderate. Ertugliflozin and Glipizide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Adding ertugliflozin to a sulfonylurea increases the risk of hypoglycemia. This is described in product labeling.
How serious is the interaction between Ertugliflozin and Glipizide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a lower glipizide dose when ertugliflozin is added. Monitor blood glucose and educate on hypoglycemia.
What other medicines interact with Glipizide?
MediHelp also lists interactions of Glipizide with, for example, Disopyramide, Fluconazole, Insulin degludec-liraglutide. The full list is on the Glipizide page.
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