Drug interactions
Ertugliflozin + Insulin aspart-insulin aspart protamine
Severity: Moderate
Ertugliflozin and Insulin aspart-insulin aspart protamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ertugliflozin combined with insulin increases hypoglycemia risk. Ketoacidosis can also occur with SGLT2 inhibitors, particularly if insulin is reduced too far.
What this interaction means in plain words
Ertugliflozin and Insulin aspart-insulin aspart protamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ertugliflozin belongs to Endocrine; Insulin aspart-insulin aspart protamine belongs to Endocrine.
Why it happens
Additive glucose lowering via insulin-independent urinary glucose excretion.
What to do
Consider a lower insulin dose when initiating ertugliflozin and monitor glucose closely. Check ketones if the patient has nausea, vomiting or malaise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin aspart-insulin aspart protamine
- Ethanol + Insulin aspart-insulin aspart protamine Major
- Insulin aspart-insulin aspart protamine + Pentamidine Major
- Insulin aspart-insulin aspart protamine + Pioglitazone Major
- Insulin aspart-insulin aspart protamine + Rosiglitazone Major
- Acarbose + Insulin aspart-insulin aspart protamine Moderate
- Albiglutide + Insulin aspart-insulin aspart protamine Moderate
Other interactions of Ertugliflozin
- Chlorpropamide + Ertugliflozin Moderate
- Ertugliflozin + Glibenclamide Moderate
- Ertugliflozin + Gliclazide Moderate
- Ertugliflozin + Glimepiride Moderate
- Ertugliflozin + Glimepiride-pioglitazone Moderate
- Ertugliflozin + Glipizide Moderate
Frequently asked questions
Can I take Ertugliflozin with Insulin aspart-insulin aspart protamine?
MediHelp rates the interaction as moderate. Ertugliflozin and Insulin aspart-insulin aspart protamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ertugliflozin combined with insulin increases hypoglycemia risk. Ketoacidosis can also occur with SGLT2 inhibitors, particularly if insulin is reduced too far.
How serious is the interaction between Ertugliflozin and Insulin aspart-insulin aspart protamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a lower insulin dose when initiating ertugliflozin and monitor glucose closely. Check ketones if the patient has nausea, vomiting or malaise.
What other medicines interact with Insulin aspart-insulin aspart protamine?
MediHelp also lists interactions of Insulin aspart-insulin aspart protamine with, for example, Ethanol, Pentamidine, Pioglitazone. The full list is on the Insulin aspart-insulin aspart protamine page.
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