Drug interactions
Ertugliflozin + Insulin aspart
Severity: Moderate
Ertugliflozin and Insulin aspart: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ertugliflozin lowers blood glucose through urinary glucose excretion, independent of insulin. Added to insulin, it can raise the frequency of hypoglycemia. Volume depletion and ketoacidosis are additional SGLT2-inhibitor concerns in insulin-treated patients.
What this interaction means in plain words
Ertugliflozin and Insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ertugliflozin belongs to Endocrine; Insulin aspart belongs to Endocrine.
Why it happens
Additive glucose-lowering effects from insulin action and SGLT2 inhibition (pharmacodynamic synergism).
What to do
Consider reducing the insulin aspart dose when starting ertugliflozin and monitor blood glucose closely. Also watch for ketoacidosis symptoms and volume depletion.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin aspart
Other interactions of Ertugliflozin
- Chlorpropamide + Ertugliflozin Moderate
- Ertugliflozin + Glibenclamide Moderate
- Ertugliflozin + Gliclazide Moderate
- Ertugliflozin + Glimepiride Moderate
- Ertugliflozin + Glimepiride-pioglitazone Moderate
- Ertugliflozin + Glipizide Moderate
Frequently asked questions
Can I take Ertugliflozin with Insulin aspart?
MediHelp rates the interaction as moderate. Ertugliflozin and Insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ertugliflozin lowers blood glucose through urinary glucose excretion, independent of insulin. Added to insulin, it can raise the frequency of hypoglycemia. Volume depletion and ketoacidosis are additional SGLT2-inhibitor concerns in insulin-treated patients.
How serious is the interaction between Ertugliflozin and Insulin aspart?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the insulin aspart dose when starting ertugliflozin and monitor blood glucose closely. Also watch for ketoacidosis symptoms and volume depletion.
What other medicines interact with Insulin aspart?
MediHelp also lists interactions of Insulin aspart with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin aspart page.
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