Drug interactions
Ertugliflozin + Insulin detemir
Severity: Moderate
Ertugliflozin and Insulin detemir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining ertugliflozin with insulin increases the risk of hypoglycemia. Ketoacidosis risk with SGLT2 inhibitors also needs attention when insulin doses are reduced.
What this interaction means in plain words
Ertugliflozin and Insulin detemir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ertugliflozin belongs to Endocrine; Insulin detemir belongs to Endocrine.
Why it happens
Ertugliflozin increases urinary glucose excretion independently of insulin, adding to insulin's glucose-lowering effect.
What to do
Consider reducing the insulin dose when starting ertugliflozin and monitor glucose closely. Do not withdraw insulin excessively, and check for ketosis if the patient becomes unwell.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin detemir
Other interactions of Ertugliflozin
- Chlorpropamide + Ertugliflozin Moderate
- Ertugliflozin + Glibenclamide Moderate
- Ertugliflozin + Gliclazide Moderate
- Ertugliflozin + Glimepiride Moderate
- Ertugliflozin + Glimepiride-pioglitazone Moderate
- Ertugliflozin + Glipizide Moderate
Frequently asked questions
Can I take Ertugliflozin with Insulin detemir?
MediHelp rates the interaction as moderate. Ertugliflozin and Insulin detemir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining ertugliflozin with insulin increases the risk of hypoglycemia. Ketoacidosis risk with SGLT2 inhibitors also needs attention when insulin doses are reduced.
How serious is the interaction between Ertugliflozin and Insulin detemir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the insulin dose when starting ertugliflozin and monitor glucose closely. Do not withdraw insulin excessively, and check for ketosis if the patient becomes unwell.
What other medicines interact with Insulin detemir?
MediHelp also lists interactions of Insulin detemir with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin detemir page.
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