Drug interactions
Ertugliflozin + Insulin lispro
Severity: Moderate
Ertugliflozin and Insulin lispro: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ertugliflozin lowers blood glucose by promoting urinary glucose excretion, and combined with insulin it raises hypoglycemia risk. SGLT2 inhibitors also carry a ketoacidosis risk, which is relevant when insulin doses are reduced.
What this interaction means in plain words
Ertugliflozin and Insulin lispro can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ertugliflozin belongs to Endocrine; Insulin lispro belongs to Endocrine.
Why it happens
Insulin-independent glucose lowering through SGLT2 inhibition adds to the effect of exogenous insulin.
What to do
Consider lowering the insulin lispro dose when ertugliflozin is started and monitor blood glucose closely. Avoid excessive insulin reduction and monitor for ketoacidosis.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ertugliflozin and Insulin lispro, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Insulin lispro
Other interactions of Ertugliflozin
- Chlorpropamide + Ertugliflozin Moderate
- Ertugliflozin + Glibenclamide Moderate
- Ertugliflozin + Gliclazide Moderate
- Ertugliflozin + Glimepiride Moderate
- Ertugliflozin + Glimepiride-pioglitazone Moderate
- Ertugliflozin + Glipizide Moderate
Frequently asked questions
Can I take Ertugliflozin with Insulin lispro?
MediHelp rates the interaction as moderate. Ertugliflozin and Insulin lispro can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ertugliflozin lowers blood glucose by promoting urinary glucose excretion, and combined with insulin it raises hypoglycemia risk. SGLT2 inhibitors also carry a ketoacidosis risk, which is relevant when insulin doses are reduced.
How serious is the interaction between Ertugliflozin and Insulin lispro?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider lowering the insulin lispro dose when ertugliflozin is started and monitor blood glucose closely. Avoid excessive insulin reduction and monitor for ketoacidosis.
What other medicines interact with Insulin lispro?
MediHelp also lists interactions of Insulin lispro with, for example, Alogliptin-pioglitazone, Ethanol, Metreleptin. The full list is on the Insulin lispro page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
