Drug interactions
Ertugliflozin + Insulin neutral human-insulin isophane protamine human
Severity: Moderate
Ertugliflozin and Insulin neutral human-insulin isophane protamine human: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ertugliflozin lowers glucose by promoting urinary glucose excretion, which adds to insulin's effect and raises the risk of hypoglycemia. Insulin dose reductions must be balanced against the risk of ketoacidosis.
What this interaction means in plain words
Ertugliflozin and Insulin neutral human-insulin isophane protamine human can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ertugliflozin belongs to Endocrine; Insulin neutral human-insulin isophane protamine human belongs to Endocrine.
Why it happens
Additive glucose-lowering effects of SGLT2 inhibition and insulin.
What to do
Lower the insulin dose when starting ertugliflozin and monitor glucose closely; check ketones if the patient becomes unwell.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin neutral human-insulin isophane protamine human
- Ethanol + Insulin neutral human-insulin isophane protamine human Major
- Insulin neutral human-insulin isophane protamine human + Pentamidine Major
- Insulin neutral human-insulin isophane protamine human + Rosiglitazone Major
- Acarbose + Insulin neutral human-insulin isophane protamine human Moderate
- Albiglutide + Insulin neutral human-insulin isophane protamine human Moderate
- Alogliptin + Insulin neutral human-insulin isophane protamine human Moderate
Other interactions of Ertugliflozin
- Chlorpropamide + Ertugliflozin Moderate
- Ertugliflozin + Glibenclamide Moderate
- Ertugliflozin + Gliclazide Moderate
- Ertugliflozin + Glimepiride Moderate
- Ertugliflozin + Glimepiride-pioglitazone Moderate
- Ertugliflozin + Glipizide Moderate
Frequently asked questions
Can I take Ertugliflozin with Insulin neutral human-insulin isophane protamine human?
MediHelp rates the interaction as moderate. Ertugliflozin and Insulin neutral human-insulin isophane protamine human can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ertugliflozin lowers glucose by promoting urinary glucose excretion, which adds to insulin's effect and raises the risk of hypoglycemia. Insulin dose reductions must be balanced against the risk of ketoacidosis.
How serious is the interaction between Ertugliflozin and Insulin neutral human-insulin isophane protamine human?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Lower the insulin dose when starting ertugliflozin and monitor glucose closely; check ketones if the patient becomes unwell.
What other medicines interact with Insulin neutral human-insulin isophane protamine human?
MediHelp also lists interactions of Insulin neutral human-insulin isophane protamine human with, for example, Ethanol, Pentamidine, Rosiglitazone. The full list is on the Insulin neutral human-insulin isophane protamine human page.
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